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Thomas Mehrling Selected Research

tinostamustine

11/2018Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis.
10/2018Establishment and Characterization of a Reliable Xenograft Model of Hodgkin Lymphoma Suitable for the Study of Tumor Origin and the Design of New Therapies.
6/2018Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models.
1/2018The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.

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Thomas Mehrling Research Topics

Disease

5Neoplasms (Cancer)
10/2018 - 01/2016
2Glioblastoma (Glioblastoma Multiforme)
06/2018 - 01/2018
1Glomerulonephritis
11/2018
1Inflammation (Inflammations)
11/2018
1Vasculitis (Vasculitides)
11/2018
1Microscopic Polyangiitis
11/2018
1Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
11/2018
1Hodgkin Disease (Hodgkin's Disease)
10/2018
1Brain Neoplasms (Brain Tumor)
06/2018
1Lymphoma (Lymphomas)
06/2018
1Triple Negative Breast Neoplasms
06/2018
1Vomiting
01/2015
1Nausea
01/2015
1Burkitt Lymphoma (Burkitt's Lymphoma)
07/2014
1Central Nervous System Diseases (CNS Diseases)
07/2014
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
07/2014
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
08/2009

Drug/Important Bio-Agent (IBA)

4tinostamustineIBA
11/2018 - 01/2018
2Histone Deacetylase InhibitorsIBA
11/2018 - 10/2018
2Alkylating AgentsIBA
11/2018 - 01/2018
2Immunoconjugates (Immunoconjugate)IBA
08/2018 - 02/2018
1Immunoglobulin G (IgG)IBA
11/2018
1Adrenal Cortex Hormones (Corticosteroids)IBA
11/2018
1AutoantibodiesIBA
11/2018
1AutoantigensIBA
11/2018
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2018
1Peroxidase (Myeloperoxidase)IBA
11/2018
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
11/2018
1Therapeutic UsesIBA
06/2018
1Histone Deacetylases (Histone Deacetylase)IBA
06/2018
1AntigensIBA
02/2018
1Cytotoxins (Cytolysins)IBA
02/2018
1Temozolomide (Temodar)FDA LinkGeneric
01/2018
1Bendamustine HydrochlorideFDA Link
01/2018
1Serotonin 5-HT3 Receptor AntagonistsIBA
01/2015
1Rituximab (Mabthera)FDA Link
07/2014
1forodesineIBA
08/2009

Therapy/Procedure

6Therapeutics
11/2018 - 07/2014
4Drug Therapy (Chemotherapy)
02/2018 - 07/2014
1Radiotherapy
01/2018